The Preparedness, Alert and Response: Lessons Learned in Europe from Last Cross-Border Health Infectious Threats conference is a major conference that will address the issue of improving the capabilities of Reference Centers in Public Health to protect efficiently European citizens from threats to their health. The event is supported by the Consumer, Health, Agriculture and Food Executive Agency (Chafea) for the dissemination of the 2008-2013 and 2014-2016 Health Programme results and organized by Instituto de Salud Carlos III, for the commemoration of the 30th Anniversary of the creation of the ISCIII.